Prolozone (Ozone Orthopedic Injections)
What is Prolozone?
Prolozone therapy is a medical treatment that involves the injection of a mixture of ozone gas and various nutrients into areas of the body, such as joints, ligaments, and soft tissues. The goal of prolozone therapy is to stimulate tissue repair, reduce inflammation, and promote healing in areas that may be experiencing chronic pain or musculoskeletal conditions. Pioneered by Dr. Shallenberger, this method of Ozone Therapy treatment is highly effective for all forms of joint and musculoskeletal pain. By utilizing the oxygen in ozone, the damaged tissues, joint, ligaments and tendons can regenerate.
CLICK HERE to read Dr. Shallenberger’s Article, “Wonder Why? Prolozone-Regenerating Joints and Eliminating Pain.”
- Chronic Joint Pain: Prolozone can provide relief for individuals suffering from chronic joint pain caused by conditions such as osteoarthritis or joint instability.
- Ligament and Tendon Injuries: It is effective in treating ligament and tendon injuries, such as sprains, strains, or tears, by strengthening the weakened connective tissue.
- Back Pain: Prolozone injections can target the ligaments and muscles in the spine to alleviate chronic back pain, including pain associated with degenerative disc disease or spinal instability.
- Sports Injuries: Athletes often benefit from prolozone by accelerating the healing process and regaining optimal function after sports-related injuries, such as tennis elbow, rotator cuff injuries, or knee ligament sprains.
Benefits of Prolozone
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- Non-surgical Approach: Prolozone offers a non-surgical alternative for individuals who prefer to avoid invasive procedures or are not candidates for surgery.
- Minimal Downtime: Since prolozone is minimally invasive, it typically requires minimal downtime, allowing patients to resume their normal activities shortly after the procedure.
- Long-term Relief: While the full benefits may take several weeks to manifest, prolozone can provide long-term relief by addressing the underlying cause of musculoskeletal pain and promoting tissue repair and regeneration.
- Improved Functionality: By strengthening the weakened connective tissue and restoring stability to the affected joints, prolozone can improve mobility, range of motion, and overall functionality.
How Does It Work?
Prolozone is similar to Prolotherapy; however, by utilizing oxygen/ozone we can actually supercharge the treatment. This results in a faster healing time, fewer injections and less pain. With Prolozone Therapy, the affected area is anesthetized with procaine, a local anesthetic. After the numbing medicine, a small amount of ozone gas is injected with other nutrients such as dextrose, B vitamins, into and around the joints, subcutaneous tissues, or in the muscle tissue. Prolozone works by providing energy-producing and healing oxygen to stimulate cellular growth factors which can reconstruct damaged or weakened connective tissue in and around joints.
Am I A Good Candidate?
Prolozone injections can help to treat: sciatica, joint injuries, rotator cuff tears, shoulder pain, knee injuries. Ozone injection therapy is especially effective at regenerating the cartilage in damaged knees, shoulders, backs, and hips. It is a wonderful alternative to surgery with a 75% chance for the pain to be relieved and normal function to be restored permanently.
What Should I Expect?
The response rate and recovery depends upon the patient’s healing abilities and the level of injury. Most patients require 4-6 treatments, but it may take as little as one treatment or as many as 8 depending on the severity of the injury.
In 2018 at 65, my doctor told me to expect a right hip replacement in the future. I told her I’m not ready for that and left. Six years later, it still hurt, sometime causing me to limp. I could barely reach my shoe to tie it. I had ozone injections in the past, but for minor problems. After discussing my situation with Dr. Jeanne, I decided to try ozone in my hip, three injections over six weeks. I felt immediate relief. My hip moves smoothly with no pain. My limp has gone away. I can tie my shoes easily. I don’t feel the fatigue in my lower back that I used to from over taxing other muscles. I feel I am 99% better. I am totally pleased and relieved. Thank you Dr. Jeanne and Christine! I recommend trying ozone treatment to anyone with joint pain.
-Tom Williams, Steamboat Springs
What is Prolotherapy & how does it work?
Musculoskeletal pain and joint injuries can significantly impact an individual’s quality of life, hindering mobility and causing discomfort. While there are various treatment options available, prolotherapy has emerged as a promising alternative for those seeking non-surgical interventions.
Prolotherapy is used for musculoskeletal pain or injury which is either unresolved after eight weeks, or (if earlier) where enhanced healing is desired. Prolotherapy works by raising growth factor levels or effectiveness to promote tissue repair or growth. It can be used years after the initial pain or problem began, as long as the person is healthy. Because Prolotherapy works to repair weak and painful joint areas, it is a long-term solution rather than a temporary measure such as drugs or Cortisone.
Prolotherapy, also known as regenerative injection therapy or proliferation therapy, is a minimally invasive procedure that involves the injection of an irritant solution into damaged or weakened connective tissue, such as ligaments or tendons, to stimulate the body’s natural healing response. The solution typically contains substances like dextrose, saline, or other agents that promote inflammation and stimulate tissue repair.
How Prolotherapy Works
When the irritant solution is injected into the targeted area, it triggers a controlled inflammatory response. This inflammation signals the body to initiate the healing process by increasing blood flow, promoting the production of growth factors, and stimulating the proliferation of fibroblasts and collagen, which are essential for tissue repair and regeneration.
Research shows +80% of patients treated the prolotherapy report a good or excellent result.
Conditions Treated with Prolotherapy
Prolotherapy is commonly used to treat various musculoskeletal conditions and injuries, including:
- Chronic Joint Pain: Prolotherapy can provide relief for individuals suffering from chronic joint pain caused by conditions such as osteoarthritis or joint instability.
- Ligament and Tendon Injuries: It is effective in treating ligament and tendon injuries, such as sprains, strains, or tears, by strengthening the weakened connective tissue.
- Back Pain: Prolotherapy injections can target the ligaments and muscles in the spine to alleviate chronic back pain, including pain associated with degenerative disc disease or spinal instability.
- Sports Injuries: Athletes often benefit from prolotherapy to accelerate the healing process and regain optimal function after sports-related injuries, such as tennis elbow, rotator cuff injuries, or knee ligament sprains.
The Prolotherapy Procedure
During a prolotherapy session, the healthcare provider will first assess the patient’s medical history and perform a physical examination to determine the appropriate treatment plan. The targeted area is cleaned, and a local anesthetic may be applied to minimize discomfort during the procedure.
Next, the irritant solution is injected directly into the damaged or weakened tissue using a thin needle and guided by imaging techniques, such as ultrasound or fluoroscopy, to ensure precise placement. Multiple injections may be administered during a single session, depending on the extent of the injury and the patient’s response to treatment.
Benefits of Prolotherapy
- Non-surgical Approach: Prolotherapy offers a non-surgical alternative for individuals who prefer to avoid invasive procedures or are not candidates for surgery.
- Minimal Downtime: Since prolotherapy is minimally invasive, it typically requires minimal downtime, allowing patients to resume their normal activities shortly after the procedure.
- Long-term Relief: While the full benefits may take several weeks to manifest, prolotherapy can provide long-term relief by addressing the underlying cause of musculoskeletal pain and promoting tissue repair and regeneration.
- Improved Functionality: By strengthening the weakened connective tissue and restoring stability to the affected joints, prolotherapy can improve mobility, range of motion, and overall functionality.

